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		<title>FDA Greenlights First Human Trial of Kratom to Treat Opioid Use Disorder</title>
		<link>/fda-human-trial-kratom-opioid-use-disorder/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Thu, 04 Jun 2026 14:14:15 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[7-OH]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[opioids]]></category>
		<guid isPermaLink="false">/?p=24011</guid>

					<description><![CDATA[<p>The Food and Drug Administration has approved an Investigational New Drug Application (IND) to study mitragynine, the main psychoactive compound ...</p>
<p>The post <a href="/fda-human-trial-kratom-opioid-use-disorder/">FDA Greenlights First Human Trial of Kratom to Treat Opioid Use Disorder</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">T</span>he Food and Drug Administration has approved an Investigational New Drug Application (IND) to study <span style="font-weight: 400;">mitragynine, the m</span><span style="font-weight: 400;">ain psychoactive compound in kratom, as a potential treatment for opioid use disorder (OUD). The National Institutes of Health-sponsored study will be th</span><span style="font-weight: 400;">e</span><span style="font-weight: 400;"> first randomized, double-blind, placebo-controlled clinical trial evaluating mitragynine in humans. It also gives some indication of the Trump administration&#8217;s intentions regarding the paradoxical, highly contentious regulatory landscape that </span>kratom shares with <span style="font-weight: 400;">mitragynine&#8217;s</span> more potent form, 7-OH.</p>
<p><span style="font-weight: 400;">“This research study is the first time the new medication MG001 is being tested in people,” </span><a href="https://clinicaltrials.gov/study/NCT07204171#study-overview"><span style="font-weight: 400;">states</span></a><span style="font-weight: 400;"> a National Institute on Drug Abuse summary. “MG001 is a formulation of mitragynine, a compound that comes from a plant called Mitragyna speciosa (sometimes known as kratom), which some people use on their own to help manage symptoms of opioid withdrawal. The purpose of this study is to understand how safe MG001 is, how well it is tolerated, and how the body processes it.”</span></p>
<p><span style="font-weight: 400;">Researchers from NIDA and the University of Florida developed a “purified formulation&#8221; of mitragynine, and anticipate enrolling about 32 volunteers. The study is part of the federal </span><span style="font-weight: 400;">Helping to End Addiction Long-term® (HEAL) Initiative. </span><span style="font-weight: 400;">In a June 1 </span><a href="https://www.nih.gov/news-events/news-releases/nih-research-clears-way-study-experimental-treatment-opioid-use-disorder"><span style="font-weight: 400;">announcement</span></a><span style="font-weight: 400;"> that the IND had taken effect, NIDA Director Nora Volkow described it as a “major step toward expanding treatment options for the millions of Americans struggling with opioid use disorder.”</span></p>
<p>Kratom has for years been informally used <a href="/kratom-mental-health-opioids/">to manage symptoms of OUD</a>. It&#8217;s also prompted various attempts to ban it. But more recently, bolstered by the Drug Enforcement Administration&#8217;s demonization of synthetic drugs in contrast to plant-based drugs, these attempts have honed in on 7-OH.</p>
<p><span style="font-weight: 400;">7-</span><span style="font-weight: 400;">hydroxymitragynine, commonly known as 7</span><span style="font-weight: 400;">-OH, is an active byproduct of mitragynine, and so small quantities of it are naturally present in all kratom products. But it’s also been synthetically concentrated to make more products that are much more potent than traditional kratom products, and these are what public officials are referring to when they talk about 7-OH.</span></p>
<blockquote><p><span style="font-weight: 400;">The FDA&#8217;s decision appears to confirm a somewhat ambiguous statement of support from President Trump a few weeks earlier. </span></p></blockquote>
<p><a href="/7-oh-kratom-fda-csa-scheduling/"><span style="font-weight: 400;">In July 2025</span></a><span style="font-weight: 400;"> the FDA recommended placing 7-OH under Schedule I of the Controlled Substances Act, and formally initiated the review process with the DEA. The agency </span><a href="https://www.fda.gov/news-events/press-announcements/fda-takes-steps-restrict-7-oh-opioid-products-threatening-american-consumers"><span style="font-weight: 400;">explained</span></a><span style="font-weight: 400;"> that it was targeting 7-OH specifically, and “not focused on natural kratom leaf products.”</span></p>
<p><span style="font-weight: 400;">Since then</span><span style="font-weight: 400;">, amid an explosion of interest from media and law enforcement, 7-OH has become the subject of multiple public health alerts including </span><a href="/7-oh-los-angeles-county-overdose-deaths/"><span style="font-weight: 400;">misleading claims</span></a><span style="font-weight: 400;"> about overdose deaths.</span><span style="font-weight: 400;"> Media began using the moniker </span><a href="/7-oh-gas-station-drugs/"><span style="font-weight: 400;">“gas station drugs”</span></a><span style="font-weight: 400;"> to refer to 7-OH and other unregulated <a href="/cychlorphine-media-synthetic-opioids/">synthetic opioids</a> and <a href="/stimulant-harm-reduction-synthetic-cannabinoids/">cannabinoids</a>. </span><span style="font-weight: 400;">Legislators </span><a href="/synthetic-drug-kratom-7-oh/"><span style="font-weight: 400;">proposed bills</span></a><span style="font-weight: 400;"> to ban all kratom products, or ban all 7-OH products, or regulate kratom while banning 7-OH, and so on. </span><a href="/kratom-bills-prohibition-regulation/"><span style="font-weight: 400;">Some of these bills have advanced</span></a><span style="font-weight: 400;"> in the same states at the same time. Kratom products by definition include all 7-OH products, but technically 7-OH is also present in all kratom products, prompting a lot of discussions about thresholds—similar to how hemp-derived CBD products have to contain less than 0.3 percent THC, otherwise they’re legally considered marijuana.</span></p>
<p><span style="font-weight: 400;">But 10 months later, the DEA has not moved to schedule 7-OH. Meanwhile it seems increasingly likely that the administration plans to eventually approve kratom as a treatment for OUD, which would make it ineligible for Schedule I and thus complicate any attempt to place 7-OH under Schedule I (not that the DEA would be unwilling <a href="/doj-reclassifies-medical-marijuana-schedule-iii/">to proceed</a> with that kind of thing). The FDA clearing NIDA to begin human trials for its mitragynine product appears to confirm a somewhat ambiguous statement of support from President Donald Trump a few weeks earlier. </span></p>
<p><span style="font-weight: 400;">“We’re looking very seriously at natural 7-OH and getting that approved—natural 7-OH,” Trump </span><a href="https://x.com/GrantSmithEllis/status/2053882800609091857"><span style="font-weight: 400;">said</span></a><span style="font-weight: 400;"> at an Oval Office event in May. “And we’ll take a look at that very strongly, I think [</span><span style="font-weight: 400;">Centers for Medicare & Medicaid Services Administrator </span><span style="font-weight: 400;">Mehmet] Oz and everybody were looking to see if we can do something there. A lot of people are asking for it.”</span></p>
<p>The phrase &#8220;natural 7-OH&#8221; has done nothing to clear up confusion about synthetic 7-OH versus plant-based kratom, but Trump probably meant the latter.</p>
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<p><em>Image (cropped) via <a href="https://commons.wikimedia.org/wiki/File:Kratom_leaves.jpg">Wikimedia Commons</a>/<a href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons 4.0</a></em></p>
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		<title>State Bills to Regulate Kratom Advance, Alongside Ones to Ban It</title>
		<link>/kratom-bills-prohibition-regulation/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Fri, 10 Apr 2026 15:56:24 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[7-OH]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[opioids]]></category>
		<guid isPermaLink="false">/?p=22791</guid>

					<description><![CDATA[<p>Nine months after Rhode Island passed a law regulating the sale of kratom, the partial opioid agonist that has divided ...</p>
<p>The post <a href="/kratom-bills-prohibition-regulation/">State Bills to Regulate Kratom Advance, Alongside Ones to Ban It</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">N</span>ine months after Rhode Island passed a law regulating the sale of kratom, the partial opioid agonist that has divided legislators across the country about how to respond to <a href="/7-oh-gas-station-drugs/"><span style="font-weight: 400;">“gas station drugs,”</span></a><span style="font-weight: 400;"> those regulations are now in effect. Rhode Island had designated kratom a Schedule I controlled substance in 2017, making it the first and so far only state to overturn such a ban.</span></p>
<p><span style="font-weight: 400;">That new law requires kratom products to be kept behind sales counters and not sold to anyone under 21. It does not allow for the sale of </span>7-hydroxymitragynine (7-OH) products, which are more potent because they contain a synthetically concentrated form of the main psychoactive compound in kratom. Both kratom and 7-OH have been the subject of increasing attention from media and lawmakers ever since 7-OH was <a href="/7-oh-kratom-fda-csa-scheduling/">recommended for federal Schedule I</a><span style="font-weight: 400;"> by the Food and Drug Administration in July 2025, shortly after Rhode Island passed its reform.</span></p>
<p><span style="font-weight: 400;">“Rhode Island is facing a deadly opioid crisis, and we must embrace every tool available to reduce harm and to save lives,” Senate President Pro Tempore Hanna M. Gallo (D) </span><a href="https://www.rilegislature.gov/pressrelease/_layouts/RIL.PressRelease.ListStructure/Forms/DisplayForm.aspx?List=c8baae31%2D3c10%2D431c%2D8dcd%2D9dbbe21ce3e9&ID=375811&Web=2bab1515%2D0dcc%2D4176%2Da2f8%2D8d4beebdf488"><span style="font-weight: 400;">stated</span></a><span style="font-weight: 400;"> in July 2025. “Kratom is used by many to manage pain and to ease opioid withdrawal symptoms. Rhode Island remains the only New England state where this substance is prohibited. This legislation replaces prohibition with sensible regulations.”</span></p>
<p><span style="font-weight: 400;">Seven states and the District of Columbia currently have full kratom bans like the one Rhode Island overturned. (</span><span style="font-weight: 400;">Louisiana, which enacted its full kratom ban in August 2025, is currently considering a </span><a href="https://www.legis.la.gov/legis/ViewDocument.aspx?d=1446824"><span style="font-weight: 400;">bill</span></a><span style="font-weight: 400;"> that would revise that ban so it only applied to 7-OH products.) </span><span style="font-weight: 400;">In Connecticut, where the most recent of these bans went into effect March 25, reports are already emerging that many consumers, some of whom are struggling to find withdrawal support, are driving across state lines to buy it from Massachusetts or New York.</span></p>
<p><span style="font-weight: 400;">“Some sellers lost a lot of money—threw it away or sold it at a discount,” smoke shop </span><span style="font-weight: 400;">owner Omar Nasser </span><span style="font-weight: 400;">told the </span><a href="https://lakevillejournal.com/connecticuts-kratom-ban-spurs-cross-border-demand-exposes-addiction-challenges"><i><span style="font-weight: 400;">Lakeville Journal</span></i></a><span style="font-weight: 400;">. “It would be no surprise if others are taking it over the border into New York to sell it or are selling it under the table.”</span></p>
<blockquote><p><span style="font-weight: 400;">A growing number of</span><span style="font-weight: 400;"> states have introduced consumer protection bills that would regulate kratom alongside other legislation that would ban it.</span></p></blockquote>
<p><span style="font-weight: 400;">With the decision to ban 7-OH at the federal level still pending, many states moved to schedule it under their own versions of the Controlled Substance Act, which has been complicated by the fact that many of them are trying to regulate kratom at the same time—kratom naturally contains small amounts of 7-OH. While the proposed bans have tended to focus on 7-OH products rather than on the broader category of kratom products, a growing number of</span><span style="font-weight: 400;"> states have introduced consumer protection bills that would regulate kratom alongside other legislation that would ban it. </span></p>
<p><span style="font-weight: 400;">South Carolina already enacted a consumer protection act regulating kratom in 2025, and is now considering legislation to reverse course and ban it instead. </span><span style="font-weight: 400;">A Michigan bill to regulate kratom stalled in November 2025, while in late March a bill that would ban kratom crossed over from the House to the Senate. </span><span style="font-weight: 400;">Iowa also recently advanced a House bill that would ban kratom under Schedule I, after narrowly rejecting an </span><a href="https://www.legis.iowa.gov/docs/publications/AMDI/91/H8168.pdf"><span style="font-weight: 400;">amendment</span></a><span style="font-weight: 400;"> proposed by </span><span style="font-weight: 400;"> Rep. Ray Sorenson (R)</span><span style="font-weight: 400;"> that would have regulated the plant instead.</span></p>
<p><span style="font-weight: 400;">“I believe the government has a role in protecting public safety, especially when it comes to minors, but when it comes to adults making decisions about legal products, we should be cautious about expanding criminal prohibitions,” Sorenson said according to </span><a href="https://www.iowapublicradio.org/state-government-news/2026-03-18/kratom-drug-ban-bill-iowa-house"><span style="font-weight: 400;">Iowa Public Radio</span></a><span style="font-weight: 400;">. &#8220;We need to target the real problem: unsafe products.”</span></p>
<p><span style="font-weight: 400;">At this point in the legislative session many of the regulation bills and prohibition bills alike have already died in committee or been postponed. But multiple states, including Delaware, Idaho, Illinois, Ohio and Tennessee, are still considering both.</span></p>
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<p><em>Image (cropped) via <a href="https://www.tn.gov/content/dam/tn/health/2026-notcom/2026-Kratom-Brief.pdf">Tennessee Department of Health</a></em></p>
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		<title>The Campaign to Ban 7-OH and &#8220;Gas Station Drugs&#8221; Shouldn&#8217;t Take Long</title>
		<link>/7-oh-gas-station-drugs/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Wed, 10 Dec 2025 16:54:40 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[7-OH]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[synthetic drugs]]></category>
		<guid isPermaLink="false">/?p=22160</guid>

					<description><![CDATA[<p>The more people become interested in banning 7-hydroxymitragynine, better-known as 7-OH, the more we&#8217;re going to see of the same ...</p>
<p>The post <a href="/7-oh-gas-station-drugs/">The Campaign to Ban 7-OH and &#8220;Gas Station Drugs&#8221; Shouldn&#8217;t Take Long</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">T</span>he more people become interested in banning <span style="font-weight: 400;">7-hydroxymitragynine, better-known as 7-OH, the more we&#8217;re going to see of the same </span><span style="font-weight: 400;">propaganda tactic that&#8217;s used for vapes and novel synthetic drugs: Anything could be in there, so there&#8217;s no need to explain the threat too precisely. </span></p>
<p><span style="font-weight: 400;"><a href="/7-oh-los-angeles-county-overdose-deaths/">“7-OH”</a> refers to a synthetically concentrated, potent form of a compound found in kratom, and is </span><a href="/7-oh-kratom-fda-csa-scheduling/"><span style="font-weight: 400;">considered an opioid</span></a><span style="font-weight: 400;"> by the Food and Drug Administration. In July the FDA recommended that 7-OH be banned under Schedule I of the Controlled Substances Act, and in the wake of that announcement state attorneys general and local elected officials have become increasingly interested in </span><a href="/7-oh-los-angeles-county-overdose-deaths/"><span style="font-weight: 400;">implying it has a significant role in the overdose crisis</span></a><span style="font-weight: 400;"> and rates of substance use disorder.</span></p>
<p><span style="font-weight: 400;">The Drug Enforcement Administration has not yet scheduled 7-OH under the CSA, meaning possession is not federally banned. Sale and distribution are banned when it&#8217;s marketed as a food additive because the FDA hasn&#8217;t approved it as such, but in many states 7-OH products are still sold in</span><span style="font-weight: 400;"> gas stations, </span>smoke shops <span style="font-weight: 400;">and convenience stores.</span></p>
<p><span style="font-weight: 400;">For example, on December 4, New Jersey introduced a </span><a href="https://pub.njleg.state.nj.us/Bills/2024/A6500/6145_I1.PDF"><span style="font-weight: 400;">bill</span></a><span style="font-weight: 400;"> that would classify 7-OH as a Schedule I substance under state law. A first-time conviction for sale or distribution could be punishable by up to 18 months in prison. For a second conviction, the maximum prison term would be five years; for subsequent convictions it would be 10 years. All of these would come with accompanying charges for violating the state’s consumer fraud act.</span></p>
<p>&#8220;[Consumers are] easily able to purchase products with concentrated levels of 7-OH online and in gas stations, corner stores and vape shops,&#8221; the bill states. &#8220;[M]any of these products contain levels of 7-OH that can be as additive [<em>sic</em>] as opioids.&#8221;</p>
<blockquote><p><span style="font-weight: 400;">The consumer alert is technically about 7-OH, but also references kratom, synthetic opioids and “gas station” supplements somewhat interchangeably. </span></p></blockquote>
<p>In a D<span style="font-weight: 400;">ecember 9 </span><a href="https://www.azag.gov/ag-mayes-consumer-alert-kratom"><span style="font-weight: 400;">consumer alert</span></a>, Arizona Attorney General Kris Mayes stated that products containing 7-OH are &#8220;<span style="font-weight: 400;">really dangerous and basically act like synthetic opioids,&#8221; and warned that she&#8217;s &#8220;already heard from parents whose kids have become addicted.&#8221; </span><span style="font-weight: 400;">The problem, she explained, is that even though these products are being sold to minors, </span><span style="font-weight: 400;">until law enforcement has “stronger tools&#8221; there&#8217;s little that can be done.</span></p>
<p><span style="font-weight: 400;">“In its current form, Arizona’s kratom law asks prosecutors to clear a high-bar just to prove a misdemeanor,” Mayes continued.</span><span style="font-weight: 400;"> “Most law enforcement agencies simply don’t have the labs, experts or budget to do that on a routine basis.”</span></p>
<p>Except they do, if the gist of the consumer alert is to be believed. Though Mayes&#8217; doesn&#8217;t quite say so explicitly, her solution appears to be to working with lawmakers in the upcoming legislative session to reclassify certain misdemeanors—namely sale to minors—as felonies. Under Arizona&#8217;s current law, retailers who sell kratom to anyone under 18 can be charged with a class 2 misdemeanor, which for a first-time conviction carries maximum penalties of four months&#8217; jail time, two years&#8217; probation and a $750 fine. The &#8220;stronger tools&#8221; are felony charges, not forensic resources.</p>
<p><span style="font-weight: 400;">The consumer alert is technically focused on 7-OH, but also references kratom, synthetic opioids and “gas station” supplements somewhat interchangeably. That&#8217;s becoming the norm. As is borrowing a drug-war narrative from campaigns against vapes and fentanyl—as long as something can be linked to youth overdose, even without evidence linking it to youth overdose, then it can be used to add criminal penalties where there weren’t any before, or turn misdemeanors into felonies.</span></p>
<blockquote><p><span style="font-weight: 400;">Tens of thousands of products containing or associated with 7-OH were seized in federal raids across Kansas City in early December.</span></p></blockquote>
<p><span style="font-weight: 400;">The Arizona consumer alert closely resembles one issued by Georgia Attorney General Chris Carr </span><a href="https://law.georgia.gov/press-releases/2025-11-13/consumer-alert-carr-warns-dangerous-synthetic-opioids-flooding-gas"><span style="font-weight: 400;">in November</span></a><span style="font-weight: 400;">.</span></p>
<p><span style="font-weight: 400;">“We’re staring down the next wave of the opioid crisis, and we have to take action before it’s too late,” Carr </span><a href="https://law.georgia.gov/press-releases/2025-11-13/consumer-alert-carr-warns-dangerous-synthetic-opioids-flooding-gas"><span style="font-weight: 400;">stated</span></a><span style="font-weight: 400;">. “These harmful and addictive drugs are sold like candy, and they’re putting children at risk. It’s unacceptable and it’s illegal, and there will be consequences for those who break our laws.”</span></p>
<p><span style="font-weight: 400;">Also in November, Missouri Attorney General Catherine Hanaway </span><a href="https://ago.mo.gov/attorney-general-hanaway-launches-investigation-into-major-kratom-manufacturers-and-retailers-for-potentially-dangerous-and-illegal-practices/"><span style="font-weight: 400;">opened investigations</span></a><span style="font-weight: 400;"> into six alleged kratom distributors, mainly local smoke shops, on the same day that the Department of Justice and the Food and Drug Administration opened a <a href="https://www.documentcloud.org/documents/26338216-shaman-complaint/">civil forfeiture case</a> against three Kansas City-area warehouses related to sale of 7-OH products. </span><span style="font-weight: 400;">Tens of thousands of products were subsequently seized in federal raids across Kansas City in early December.</span></p>
<p>&#8220;We have seen numerous reports of harmful health consequences in consumers, including children, who have taken 7-OH products,&#8221; Assistant Attorney General Brett A. Shumate of the DOJ&#8217;s Civil Division <a href="https://www.justice.gov/usao-wdmo/pr/justice-department-seizes-unlawful-7-oh-products-three-warehouses">stated</a> December 2. &#8220;[W]e will take action against anyone participating in the illegal distribution of these products.”</p>
<p><span style="font-weight: 400;">On December 3, Kansas City Mayor Quinton Lucas proposed </span><a href="https://kansascity.legistar.com/LegislationDetail.aspx?ID=7770752&GUID=E5C1CA51-B5BE-4CA4-9867-21FCEFBCA552"><span style="font-weight: 400;">Ordinance 251028</span></a><span style="font-weight: 400;">, a ban on “gas station drugs&#8221;—products derived from kratom and 7-OH, but also hemp-derived cannabinoids like Delta-8 and Delta-9, synthetic cannabinoids (K2/spice), synthetic cathinones (bath salts), nitrous oxide, </span><a href="https://www.fda.gov/food/hfp-constituent-updates/fda-alerts-industry-and-consumers-about-use-amanita-muscaria-or-its-constituents-food"><span style="font-weight: 400;">amanita mushrooms</span></a><span style="font-weight: 400;">, tianeptine (the original “gas station heroin”), and “other chemical analogues designed to produce psychoactive or intoxicating effects.”</span></p>
<p><span style="font-weight: 400;">“Unregulated gas station drugs are … often just as dangerous as controlled substances and have no place on our shelves when they contribute to addiction, overdoses and neighborhood instability,&#8221; Lucas stated, &#8220;particularly impacting our children.&#8221;</span></p>
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<p><em>Image (cropped) via <a href="https://www.fairfaxcounty.gov/boardofsupervisors/sites/boardofsupervisors/files/Assets/Documents/March11_Land_Use_TOBACCO_RETAIL_Corrected.pdf">Fairfax County, Virginia</a></em></p>
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		<title>Some States Try to Ban 7-OH, Others to Regulate Kratom. Some Try Both.</title>
		<link>/synthetic-drug-kratom-7-oh/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Thu, 30 Oct 2025 15:47:57 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[7-OH]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[synthetic drugs]]></category>
		<guid isPermaLink="false">/?p=21924</guid>

					<description><![CDATA[<p>On October 27, New Jersey Senator Shirley K. Turner (D) introduced a bill that would criminalize 7-hydroxymitragynine as a Schedule ...</p>
<p>The post <a href="/synthetic-drug-kratom-7-oh/">Some States Try to Ban 7-OH, Others to Regulate Kratom. Some Try Both.</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">O</span>n October 27, New Jersey Senator Shirley K. Turner (D) introduced a bill that would criminalize 7-hydroxymitragynine as a Schedule I drug under the state’s Controlled Dangerous Substances Act. Commonly known as 7-OH, the opioid-like compound has been increasingly targeted by state legislators since July, when the Food and Drug Administration <a href="/7-oh-kratom-fda-csa-scheduling/"><span style="font-weight: 400;">recommended placement </span></a><span style="font-weight: 400;">under Schedule I of the federal Controlled Substances Act.</span></p>
<p><span style="font-weight: 400;">For cases involving 1 ounce of 7-OH or less, </span><a href="https://pub.njleg.state.nj.us/Bills/2024/S5000/4772_I1.PDF"><span style="font-weight: 400;">Bill S4772</span></a><span style="font-weight: 400;"> would impose a prison term of three to five years regardless of whether the charge was for possession, manufacturing, distribution or possession with intent to manufacture or distribute. The maximum fine would be $35,000 for possession, and $75,000 for the other charges. </span><span style="font-weight: 400;">In cases involving more than an ounce, the prison term would be five to 10 years and the fine could be up to $150,000. The bill doesn’t specify how weight would be determined, but it’s reasonably likely that it would be the total weight of any kratom product with an alkaloid content that’s more than 2 percent 7-OH. </span></p>
<p><span style="font-weight: 400;">A naturally occurring alkaloid in the kratom plant, 7-OH is essentially what makes kratom psychoactive. It&#8217;s more potent than kratom&#8217;s primary alkaloid, but only </span><span style="font-weight: 400;">exists in trace amounts—under 2 percent, which is why that&#8217;s the threshold being widely used in similar legislation. Any higher than that indicates that the 7-OH isn&#8217;t naturally occurring, but was synthetically engineered, as it isn&#8217;t practical to extract concentracted 7-OH from kratom. </span></p>
<p><span style="font-weight: 400;">Though the Drug Enforcement Administration’s whole thing is obviously that all drugs are bad, its investment in painting </span><a href="/dea-cocaine-methamphetamine-synthetic-drugs/"><span style="font-weight: 400;">synthetic drugs as even worse</span></a><span style="font-weight: 400;"> has historically been convenient for anyone invested in the narrative that plant-based drugs are better. But now, efforts to legalize and regulate a plant-based drug (kratom) are bumping up against efforts to control and criminalize a synthetic drug (concentrated 7-OH) because the former contains the latter, just not as concentrated, and it&#8217;s getting a little hard to keep up.</span></p>
<p><span style="font-weight: 400;">In Michigan, a proposal to regulate the sale of kratom is on the House Regulatory Reform Committee agenda for October 30. </span><a href="https://legislature.mi.gov/documents/2025-2026/billintroduced/House/pdf/2025-HIB-4969.pdf"><span style="font-weight: 400;">House Bill 4969</span></a><span style="font-weight: 400;">, which would take effect in 2027, would ban kratom products with an alkaloid content above 2 percent 7-OH.</span></p>
<p><span style="font-weight: 400;">In Illinois, a proposal to create the Kratom Consumer Protection Act has been with the House Rules Committee since March, but recently picked up a new cosponsor. </span><a href="https://www.ilga.gov/Legislation/BillStatus?DocNum=1303&GAID=18&DocTypeID=HB&SessionID=114&GA=104"><span style="font-weight: 400;">HB 1303</span></a><span style="font-weight: 400;"> would also ban kratom products that exceed the 2-percent 7-OH threshold.</span></p>
<p><span style="font-weight: 400;">Massachusetts is considering a </span><a href="https://malegislature.gov/Bills/194/S1609"><span style="font-weight: 400;">bill</span></a><span style="font-weight: 400;"> that would regulate kratom sales through state licensing similar to cannabis dispensaries, the requirements for which make very clear that concentrated 7-OH products are off-limits. The state is also considering a different </span><a href="https://malegislature.gov/Bills/194/S1558"><span style="font-weight: 400;">bill</span></a><span style="font-weight: 400;"> that would simply ban all kratom (and thus 7-OH) products.</span></p>
<p><span style="font-weight: 400;">New York has a </span><a href="https://legislation.nysenate.gov/pdf/bills/2025/S7379"><span style="font-weight: 400;">bill</span></a><span style="font-weight: 400;"> in committee that would ban all kratom products under the state’s Schedule I. It also has </span><a href="https://legislation.nysenate.gov/pdf/bills/2025/S8136"><span style="font-weight: 400;">another</span></a><span style="font-weight: 400;"> bill that would regulate kratom while banning 7-OH above the 2-percent threshold; </span><a href="https://www.nysenate.gov/legislation/bills/2025/S8285"><span style="font-weight: 400;">another</span></a><span style="font-weight: 400;"> that would permit continued sales of any kratom products, but ban packaging that uses the words “all natural”; </span><a href="https://legislation.nysenate.gov/pdf/bills/2025/S4552A"><span style="font-weight: 400;">another</span></a><span style="font-weight: 400;"> that would ban sales to people under 21; and </span><a href="https://legislation.nysenate.gov/pdf/bills/2025/A9114"><span style="font-weight: 400;">another</span></a><span style="font-weight: 400;"> that would sale of any food or beverages containing kratom or 7-OH, which the FDA has already declared federally illegal.</span></p>
<blockquote><p><span style="font-weight: 400;">Similar to how fentanyl is </span><span style="font-weight: 400;">incessantly described</span><span style="font-weight: 400;"> as being 50 times more potent than heroin and 100 times more potent than morphine, 7-OH comes with a tagline, too.</span></p></blockquote>
<p><span style="font-weight: 400;">Similar to how fentanyl is </span><a href="/lethal-dose-fentanyl-media/"><span style="font-weight: 400;">incessantly described</span></a><span style="font-weight: 400;"> as being 50 times more potent than heroin and 100 times more potent than morphine, 7-OH comes with the tagline of being 13 times more potent than morphine. (For what it’s worth, this statistic comes from a 2002 </span><a href="https://pubs.acs.org/doi/10.1021/jm010576e"><span style="font-weight: 400;">experiment</span></a><span style="font-weight: 400;"> on guinea pig intestines; not humans.) And now that more and more legislators find themselves talking about 7-OH, they’re plugging in the same fentanyl rhetoric they know by heart; if it works for one synthetic drug, it must work for all of them.</span></p>
<p><span style="font-weight: 400;">In an October 28 </span><a href="https://www.marshall.senate.gov/wp-content/uploads/Marshall-DEA-letter.pdf"><span style="font-weight: 400;">letter</span></a><span style="font-weight: 400;"> about 7-OH products “and their analogues,” Kansas Senator Roger Marshall called for DEA Administrator Terrance Cole to “eliminate these dangerous synthetics”—</span><a href="/dea-permanent-ban-fentanyl-analogs/"><span style="font-weight: 400;">via temporary scheduling</span></a><span style="font-weight: 400;">. He went on to describe manufacturers “exploiting regulatory gaps and flooding communities with synthetic compounds” by advertising concentrated 7-OH products as kratom extracts.</span></p>
<p><span style="font-weight: 400;">“This regulatory gap blurs the distinction between a natural botanical product and a dangerous synthetic drug,” he wrote. “These products are adulterated chemical analogues engineered to deliver intense opioid-like effects that no natural Kratom product could produce.”</span></p>
<p>The recently proposed New Jersey bill does much the same thing.</p>
<p><span style="font-weight: 400;">“The FDA has issued a number of warnings and conducted seizures of illegally sold, unapproved or misbranded drug products,” the bill states, “containing potentially lethal doses of synthetic 7-OH.”</span></p>
<p><span style="font-weight: 400;">The phrase “potentially lethal dose” is borrowed from the DEA, which uses it in reference to fentanyl. The FDA’s 7-OH guidance does not describe the substance this way; it’s actually </span><a href="https://www.fda.gov/media/187899/download?attachment"><span style="font-weight: 400;">pretty explicit </span></a><span style="font-weight: 400;">that while anecdotal reports and preclinical (non-human) trials suggest there could be risk of respiratory depression with 7-OH, the fact that it was in someone’s system at the time that they died <a href="/7-oh-los-angeles-county-overdose-deaths/">does not mean it killed them</a>.</span></p>
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<p><em>Image (cropped) via <a href="http://publichealth.lacounty.gov/sapc/docs/prevention/FactSheet/7-OH%20Flyer_093025.pdf">County of Los Angeles Public Health</a></em></p>
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		<title>7-OH Did Not Cause the LA Overdose Deaths (Neither Did Kratom)</title>
		<link>/7-oh-los-angeles-county-overdose-deaths/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Wed, 17 Sep 2025 18:08:35 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[7-OH]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[opioids]]></category>
		<guid isPermaLink="false">/?p=21698</guid>

					<description><![CDATA[<p>On September 12, the Los Angeles County Department of Public Health (LACDPH) announced that 7-Hydroxymitragynine had been linked to three ...</p>
<p>The post <a href="/7-oh-los-angeles-county-overdose-deaths/">7-OH Did Not Cause the LA Overdose Deaths (Neither Did Kratom)</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">O</span>n September 12, the Los Angeles County Department of Public Health (LACDPH) <span style="font-weight: 400;">announced</span> <span style="font-weight: 400;">that 7-Hydroxymitragynine had been linked to three overdose deaths. Better known as 7-OH, the synthetically concentrated version of a compound found in the plant kratom has rapidly gained attention since</span><span style="font-weight: 400;"> the Food and Drug Administration recommended <a href="/7-oh-kratom-fda-csa-scheduling/">in July</a> that it be placed under Schedule I of the Controlled Substances Act.</span></p>
<p><span style="font-weight: 400;"><a href="https://www.sfgate.com/la/article/kratom-7-oh-california-overdose-deaths-21045738.php">Various media outlets</a> are <a href="https://www.the-independent.com/news/world/americas/synthetic-kratom-fatal-overdoses-california-b2826868.html">reporting</a> that 7-OH was directly responsible for the deaths, which is also the conclusion most people would probably draw from the </span><span style="font-weight: 400;">LACDPH <a href="http://publichealth.lacounty.gov/phcommon/public/media/mediapubhpdetail.cfm?prid=5139">press release</a>, where 7-OH was the only substance singled out in the headline.</span></p>
<p><span style="font-weight: 400;">&#8220;The Los Angeles County Department of Public Health is making residents and health care providers aware of the risks of the synthetic kratom compound known as 7-Hydroxymitragynine (7-OH) after the County of Los Angeles Medical Examiner recently identified three fatal overdoses in LA County residents between the ages of 18 to 40 years old,&#8221; LACDPH <a href="http://publichealth.lacounty.gov/phcommon/public/media/mediapubhpdetail.cfm?prid=5139">stated</a>. &#8220;Alcohol was present in all cases. The decedents were otherwise healthy, with no other substances identified as substantively contributing to their deaths.”</span></p>
<p>In medical examiner case records that <span style="font-weight: 400;">LACDPH confirmed to <em>Filter</em> correspond to the <a href="https://me.lacounty.gov/case-detail/?caseNumber=2025-06340">three</a> <a href="https://me.lacounty.gov/case-detail/?caseNumber=2025-09782">deaths</a> in question, </span><span style="font-weight: 400;">none determined 7-OH to be the primary cause of death. <a href="https://me.lacounty.gov/case-detail/?caseNumber=2025-10888">One that lists</a> cause of death as acute alcohol toxicity cites</span> 7-OH as an underlying cause alongside kratom and two antidepressants, and notes that other significant conditions included &#8220;pulmonary congestion and edema, psychiatric history with prescribed antidepressant therapy.&#8221;</p>
<p>LACDPH told <em>Filter </em>that reconciling this with description in the press release would be best addressed by the medical examiner, who had not responded as of publication time.</p>
<p>&nbsp;</p>
<p><img decoding="async" class="img-responsive aligncenter wp-image-21700 size-large" src="/wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-1024x628.png" alt="" width="640" height="393" srcset="/wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-1024x628.png 1024w, /wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-300x184.png 300w, /wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-768x471.png 768w, /wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-1536x942.png 1536w, /wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM-376x231.png 376w, /wp-content/uploads/2025/09/Screenshot-2025-09-17-at-6.34.48-AM.png 1568w" sizes="(max-width: 640px) 100vw, 640px" /></p>
<p style="text-align: center;"><em>FDA slide warning of 7-OH as an emerging public health threat</em></p>
<p>&nbsp;</p>
<p style="text-align: left;"><span style="font-weight: 400;">In August, just after the FDA recommended banning 7-OH under Schedule I of the CSA, </span><a href="https://www.legis.la.gov/legis/Law.aspx?d=1336019"><span style="font-weight: 400;">Louisiana</span></a> passed a bill that<span style="font-weight: 400;"> banned both 7-OH and kratom explicitly. </span><a href="https://www.myfloridalegal.com/newsrelease/attorney-general-james-uthmeier-files-emergency-rule-immediately-removing-dangerous-7"><span style="font-weight: 400;">Florida</span></a><span style="font-weight: 400;"> became the first state to ban 7-OH on its own. America’s Poison Centers—the organization that oversees the National Poison Data System—<a href="https://poisoncenters.org/news-alerts/13531044">reported</a> that so far in 2025 there had been 165 reports of 7-OH exposure. Of the unspecified number of patients who reported exposure to 7-OH and no other substances, more than one-third had “serious health problems” and more than two-thirds “were treated at a health care facility.”</span></p>
<p><span style="font-weight: 400;">7-OH isn&#8217;t readily detectable on standard urinalysis tests. So the data that US poison centers are going off of </span><a href="https://www.pa.gov/content/dam/copapwp-pagov/en/health/documents/topics/documents/2025%20HAN/2025-802-%208-4-%20Kratom.pdf"><span style="font-weight: 400;">is primarily self-reported</span></a><span style="font-weight: 400;">, and isn’t confirmed at a lab. The same is true of calls about kratom exposure.</span></p>
<p><span style="font-weight: 400;">“At low doses, 7-OH can have stimulant-like effects and at higher doses it has opioid-like effects,” LACDPH continued in its press release. “High doses of 7-OH and/or co-used with alcohol or other sedatives can cause severe respiratory depression and death. Again, they are unregulated and may contain unknown concentrations of 7-OH, increasing the risk of unintentional overdose.”</span></p>
<p><span style="font-weight: 400;">We tend to think of stimulants as uppers and opioids as downers, and there is obviously a lot of truth to that. But a more complete description would explain that all kinds of drugs have a stimulating effect at lo</span><span style="font-weight: 400;">wer doses, and a <a href="/meth-overamp/">sedating effect at higher doses</a>. Alcohol is a good example of this, because it&#8217;s so commonly used; most of us are probably familiar with the concept of someone getting chatty after the first couple of drinks, and passing out by the end of the night. But it&#8217;s not clear what basis there is for saying that &#8220;high doses&#8221; are linked to respiratory depression and death. 7-OH is unregulated. What constitutes a high dose, and how does someone know that&#8217;s what they&#8217;re taking?</span></p>
<blockquote><p>Prohibition and regulation are legal constructs that have very little to do with a drug&#8217;s actual benefits or harms.</p></blockquote>
<p><span style="font-weight: 400;">Advocates for 7-OH say the sudden attention to 7-OH is being manufactured by, essentially, <a href="https://www.reuters.com/press-releases/big-kratom-fake-protesters-7-oh-las-vegas-trade-show-2025-07-25/">Big Kratom</a>.</span></p>
<p>&#8220;Unfortunately, there are current efforts in a number of state legislatures to ban 7-OH, which are largely driven by a kratom organization that views 7-OH as a threat to its market share,&#8221; <a href="https://hartsupporter.com/7-oh-overview/">states</a> Holistic Alternative Recovery Trust, a nonprofit supportive of 7-OH and other opioid alternatives. &#8220;7-OH can be an invaluable harm reduction tool that should remain an option for the hundreds of thousands of consumers that rely on it. This was a <a class="c-link" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813050/" target="_blank" rel="noopener noreferrer" data-stringify-link="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813050/" data-sk="tooltip_parent">key factor</a> in <a class="c-link" href="https://cdn.prod.website-files.com/61858fcfc6543059f0617522/620c13ac9741c266fb08af52_HHS%20Rescission%20Letter%20Dr.%20Giroir%20Aug%2016%202018%20highlighted.pdf" target="_blank" rel="noopener noreferrer" data-stringify-link="https://cdn.prod.website-files.com/61858fcfc6543059f0617522/620c13ac9741c266fb08af52_HHS%20Rescission%20Letter%20Dr.%20Giroir%20Aug%2016%202018%20highlighted.pdf" data-sk="tooltip_parent">HHS’ decision</a> to reject efforts to ban kratom and 7-OH.&#8221;</p>
<p>Groups like the American Kratom Association, meanwhile, are quick to draw a distinction.</p>
<p>“The AKA is committed to protect consumers from deliberately deceptive marketing by 7-OH product manufacturers who are materially misleading and confusing consumers seeking traditional kratom products,” AKA Senior Fellow on Public Policy Mac Haddow <a href="https://www.americankratom.org/news/consumer-alert-on-7oh-products">stated</a> in January. “Any product containing a level of 7-OH that exceeds the 2 percent of the overall alkaloid content are not kratom products, and consumers looking to purchase traditional kratom products should avoid these mislabeled products.”</p>
<p><span style="font-weight: 400;">Beginning with Indiana and Wisconsin in 2014, seven states have now banned kratom. This includes Rhode Island, which in July </span><a href="https://www.rilegislature.gov/pressrelease/_layouts/RIL.PressRelease.ListStructure/Forms/DisplayForm.aspx?List=c8baae31%2D3c10%2D431c%2D8dcd%2D9dbbe21ce3e9&ID=375811&Web=2bab1515%2D0dcc%2D4176%2Da2f8%2D8d4beebdf488"><span style="font-weight: 400;">passed legislation</span></a><span style="font-weight: 400;"> to reverse its ban and plans to flip to a legal regulation model in 2026. The FDA’s recent call to ban 7-OH didn’t extend to kratom. (The agency attempted to ban kratom nearly a decade ago, but was <a href="https://www.uspharmacist.com/article/the-dea-changes-its-mind-on-kratom">overwhelmed</a> by public pushback.)</span></p>
<p><span style="font-weight: 400;">T</span>his gets confusing because many kratom stakeholders are also pushing for legal regulation of the plant, which contains the chemical compound they&#8217;re are hoping to ban (in its concentrated form). <span style="font-weight: 400;">7-OH stakeholders, meanwhile, are also arguing for regulation, and suggesting that the compound has untapped medical benefits </span><a href="https://hartsupporter.com/wp-content/uploads/2025/07/Pre-Clinical-Safety-Comparison.pdf"><span style="font-weight: 400;">while posing no more risk than kratom.</span></a></p>
<p>The important thing to remember in all this is that prohibition and regulation are legal constructs that have very little to do with a drug&#8217;s actual benefits or harms. That&#8217;s why the CSA tells us that marijuana has no medical benefits and alcohol has no potential for addiction, and the designation reserved for the most dangerous drugs of all—Schedule I—is a list of 300 synthetic cannabinoids and unpronounceable research chemicals.</p>
<p>&nbsp;</p>
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<p>&nbsp;</p>
<p><em>Images (cropped) via <a href="https://www.fda.gov/drugs/information-consumers-and-patients-drugs/hiding-plain-sight-7-oh-products">United Stated Food and Drug Administration</a></em></p>
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		<title>FDA Marks 7-OH, Kratom Compound With Opioid Effect, for CSA Schedule I</title>
		<link>/7-oh-kratom-fda-csa-scheduling/</link>
		
		<dc:creator><![CDATA[Kastalia Medrano]]></dc:creator>
		<pubDate>Thu, 31 Jul 2025 14:50:13 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[FDA]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[opioids]]></category>
		<guid isPermaLink="false">/?p=21450</guid>

					<description><![CDATA[<p>The Food and Drug Administration is recommending that 7-hydroxymitragynine, commonly referred to as 7-OH, be federally scheduled under the Controlled ...</p>
<p>The post <a href="/7-oh-kratom-fda-csa-scheduling/">FDA Marks 7-OH, Kratom Compound With Opioid Effect, for CSA Schedule I</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">T</span>he Food and Drug Administration is recommending that 7-hydroxymitragynine, commonly referred to as 7-OH, be federally scheduled under the Controlled Substances Act. The agency <a href="https://www.fda.gov/news-events/press-announcements/fda-takes-steps-restrict-7-oh-opioid-products-threatening-american-consumers">announced</a> July 29 that it had initiated the review process with the Drug Enforcement Administration, and FDA Commissioner Marty Makary has <a href="https://www.cnn.com/2025/07/29/health/kratom-derived-opioid-7-oh">suggested</a> that 7-OH should be classified as Schedule I.</p>
<p>7-OH is an active byproduct of mitragynine, which is the main psychoactive compound in the <i>Mitragyna speciosa</i> plant—similar to how delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in <i>Cannabis sativa.</i> The <i>Mitragyna speciosa</i> plant is better known as <a href="/kratom-mental-health-opioids/">kratom</a>. Essentially, 7-OH is a more potent version of kratom.</p>
<p>“The FDA is specifically targeting 7-OH &#8230; it is not focused on natural kratom leaf products,” the agency <a href="https://www.fda.gov/news-events/press-announcements/fda-takes-steps-restrict-7-oh-opioid-products-threatening-american-consumers">stated</a>. “7-OH is increasingly recognized as having potential for abuse because of its ability to bind to opioid receptors.”</p>
<p>Both mitragynine and 7-OH are considered partial opioid agonists, like <a href="/microdosing-suboxone-fentanyl/">buprenorphine</a>. In its accompanying <a href="https://www.fda.gov/drugs/information-consumers-and-patients-drugs/hiding-plain-sight-7-oh-products">report</a> on 7-OH, however, the FDA stated that “observations suggest 7-OH has pharmacological properties representative of a full <em>mu</em> opioid agonist and an associated high potential for abuse.” It also stated that &#8220;[c]linical presentations include euphoria, sedation, respiratory depression and opioid-like withdrawal syndromes, with users acknowledging its significant addiction potential.&#8221;</p>
<p>It should be noted that all of these observations and clinical presentations refer to either lab testing involving petri dishes or mice, or posts on Reddit and other online forums like Erowid.</p>
<p>The FDA’s analysis did include human post-mortem toxicology data, but the agency cautioned that it “generally cannot be discerned” whether 7-OH specifically contributed to any deaths, so there are “significant limitations in making inferences from these data.”</p>
<p>What we do know is that both supply and demand for 7-OH, or similar higher-potency kratom products, have been growing at a faster rate since 2023 compared to previous years.</p>
<p>&nbsp;</p>
<p><img loading="lazy" decoding="async" class="img-responsive aligncenter wp-image-21453 size-large" src="/wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-1024x627.png" alt="" width="640" height="392" srcset="/wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-1024x627.png 1024w, /wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-300x184.png 300w, /wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-768x470.png 768w, /wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-1536x941.png 1536w, /wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM-376x230.png 376w, /wp-content/uploads/2025/07/Screenshot-2025-07-31-at-7.12.08-AM.png 2044w" sizes="auto, (max-width: 640px) 100vw, 640px" /></p>
<p>&nbsp;</p>
<p>7-OH is not regulated, and so various products like chewable tablets or gummies can be legally sold at vape shops, gas stations, convenience stores and so forth.</p>
<p>The Centers for Forensic Science Research & Education has <a href="https://www.cfsre.org/images/content/reports/public_alerts/7-Hydroxy_Mitragynine_NPS_Discovery_033125.pdf">described</a> mitragynine, AKA plant-based kratom products, in a manner <a href="/stimulant-harm-reduction-synthetic-cannabinoids/">that recalls synthetic cannabinoids</a>: “a pharmacologically complex drug, exhibiting stimulant-like effects at low doses and sedative effects at higher doses.”</p>
<p>At a July 29 press conference, United States Secretary of Health and Human Services Robert F. Kennedy Jr. <a href="https://www.spokesman.com/stories/2025/jul/31/fda-moves-to-restrict-7-hydroxymitragynine-an-opio/">stated</a> that CSA scheduling was necessary to prevent 7-OH from becoming the fourth wave of the opioid-involved overdose crisis. It&#8217;s <a href="https://onlinelibrary.wiley.com/doi/10.1111/add.16318">widely established</a> among drug-policy researchers that after prescription analgesics, then heroin, then fentanyl, the fourth wave already began <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8154745/">around 2018 with opioid-stimulant polysubstance use</a>. But the FDA has been using this &#8220;fourth wave&#8221; framing for 7-OH, too.</p>
<p>Also on July 29, FDA Commissioner Marty Makary published an <a href="https://nypost.com/2025/07/29/opinion/beware-synthetic-kratom-7-oh-powers-a-new-opioid-crisis/">op-ed</a> in the <i>New York Post</i> warning that 7-OH could be the next wave to follow &#8220;prescription opioids, heroin and fentanyl.&#8221; He also leaned on tropes borrowed from the FDA&#8217;s anti-vaping agenda, which the agency has been featuring heavily throughout its new <a href="https://www.fda.gov/drugs/information-consumers-and-patients-drugs/hiding-plain-sight-7-oh-products">7-OH public awareness materials</a> as well.</p>
<p>&#8220;Vape shops are popping up in every neighborhood in America, but few people—even doctors—know that many of these shops are selling a dangerous new opioid,&#8221; Makary wrote in the <em>Post</em>. &#8220;Perhaps most alarming is that 7-OH products are often disguised as attractive candies, gummies and even ice cream cones that parents might never see as a risk &#8230; this synthetic opioid [is not] a safer alternative—and store owners, too, should be aware.&#8221;</p>
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<p>&nbsp;</p>
<p><em>Images (cropped) via <a href="https://www.fda.gov/drugs/information-consumers-and-patients-drugs/hiding-plain-sight-7-oh-products">Food and Drug Administration</a></em></p>
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		<title>“Lawmakers Have to Google It”: Inside the Struggle to Regulate Kratom</title>
		<link>/kratom-legal-bans/</link>
		
		<dc:creator><![CDATA[Ben Adlin]]></dc:creator>
		<pubDate>Tue, 28 Mar 2023 14:00:33 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Politics + Legalization]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[legalization]]></category>
		<category><![CDATA[opioids]]></category>
		<category><![CDATA[prohibition]]></category>
		<guid isPermaLink="false">/?p=16256</guid>

					<description><![CDATA[<p>Dozens of legislatures across the United States are currently weighing how to regulate or ban kratom, a plant with mild ...</p>
<p>The post <a href="/kratom-legal-bans/">“Lawmakers Have to Google It”: Inside the Struggle to Regulate Kratom</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">D</span>ozens of legislatures across the United States are currently weighing how to regulate or ban kratom, a plant with mild opioid-like properties that’s indigenous to Southeast Asia. It’s <a href="/kratom-use-diversifying/">used by</a> people around the world who attest to its abilities to elevate mood, boost energy, relieve pain and—perhaps most crucially in an era of mass overdose deaths—treat symptoms of opioid withdrawal and sometimes replace opioids.</p>
<p>The flurry of state-level scrutiny follows efforts in recent years by the Food and Drug Administration (FDA) and Drug Enforcement Administration (DEA) to ban the drug, which remains unregulated at the federal level.</p>
<p>A majority of states either have no current regulations or very limited rules, such as an age limit. Six states, however—Alabama, Arkansas, Indiana, Tennessee, Vermont and Wisconsin—already have kratom bans, as do a handful of local jurisdictions.</p>
<p>Some states have now proposed further bans on kratom products. Mississippi is one, although lawmakers there have seen multiple such bills fail in recent years. Louisiana lawmakers have also prefiled prohibition legislation.</p>
<p>For Mac Haddow, a lobbyist and senior fellow on public policy at the American Kratom Association, what could be a crisis is an opportunity. He’s confident that advocates can defeat the Louisiana bill, for one thing, and he can rattle off a laundry list of other bills in play around the country. He spoke to <i>Filter</i> from Vienna, Austria, where he was presenting at the United Nations Commission on Narcotic Drugs.</p>
<blockquote><p>“It really comes down to your evaluation of a harm reduction tool. “Other than that, it’s a freedom issue.”</p></blockquote>
<p>In recent years, nearly 30 US states have introduced or adopted kratom legislation, whether to ban kratom products outright or to more proactively regulate existing markets.</p>
<p>Haddow said he’s currently keeping a close eye on legislation either introduced or expected in states including Illinois, Kansas, Minnesota, Michigan, Ohio, Pennsylvania, New Jersey, New York, North Carolina, Florida and Tennessee. “I’m just trying to remember them as best I can,” he quipped.</p>
<p>His broader message is a familiar one in the drug policy reform world: He argues that state and federal kratom policies should be guided by available science and common sense, rather than backlash and misunderstanding.</p>
<p>“It really comes down to your evaluation of a harm reduction tool,” Haddow said. “Other than that, it’s a freedom issue.”</p>
<p>The past decade has seen a rush of US political activity around a substance that once flew under the radar. In 2014, the FDA banned the import and export of kratom as a dietary substance. Two years later, the DEA attempted to add kratom to Schedule I of the federal Controlled Substances Act, effectively outlawing it completely. While DEA officials reversed that position after public opposition, the FDA has continued to urge against the use of kratom and insist it has no therapeutic value.</p>
<p>Law enforcement groups have backed many of the state-level bans. In Alabama, for example, which outlawed the substance in 2016, authorities <a href="https://www.wbrc.com/story/31940368/sheriff-begins-seizing-kratom-after-governor-signs-bill-banning-the-drug/">reportedly</a> claimed that kratom products were 13 times stronger than morphine.</p>
<blockquote><p>“We’ve investigated every single autopsy report we can get our hands on. We’ve found not one that was kratom only.”</p></blockquote>
<p>Haddow says popular fears around kratom are overblown—and misplaced. He attributes the recent turbulence to a 2010 report out of Sweden that linked kratom products to nine deaths over a 12-month period.</p>
<p>The problem, Haddow said, is that kratom didn’t <i>cause</i> those deaths. “We’ve investigated every single autopsy report we can get our hands on. We’ve found not one that was kratom only.”</p>
<p>The deaths in Sweden were all associated with a single kratom product, a herbal blend called Krypton, which was sold online in Europe. While the FDA cites those deaths as linked to kratom, Haddow noted that researchers behind the original report have since said the deaths were likely caused by an adulterant, O-desmethyltramadol.</p>
<p>It’s reminiscent of the so-called “EVALI&#8221; scare of 2019, when US health authorities raised the alarm about serious and fatal lung injuries associated with vaping. Initially the Centers for Disease Control (CDC) and some state and local officials <a href="/vapes-and-lung-disease-the-cdcs-lesson-in-how-not-to-handle-an-illness-outbreak/">sought to blame</a> vaping products in general, feeding into an existing panic over youth nicotine vaping. The injuries were eventually linked instead to unregulated THC vape cartridges adulterated with vitamin E acetate.</p>
<p>Every death or serious injury Haddow has seen linked to kratom, he said, has been the result of either contamination or combining kratom with other drugs, such as opioids or benzodiazepines.</p>
<p>“I think it’s true that if you have an adulterated kratom product that you are going to have adverse health events,” he said. Likewise, if people are using kratom in an attempt to replace opioids, it would follow that some people who die of opioid-involved overdose might have kratom in their systems.</p>
<p>Similar points were being made by health experts even as states moved to ban kratom years ago. “Direct kratom overdoses from the life-threatening respiratory depression that usually occurs with opioid overdoses have not been reported,” Oliver Grundmann, a clinical professor of medicinal chemistry at the University of Florida, told <a href="https://www.vice.com/en/article/7bdqgg/why-banning-the-controversial-painkiller-kratom-could-be-bad-news-for-americas-heroin-addicts"><i>VICE</i></a> at the time of the Alabama ban.</p>
<p>Kratom itself poses fairly benign health risks, Haddow said, most commonly nausea. Serious side effects are rare and typically occur at high doses. When consumed in its plant form (often in teas, powders or capsules), kratom has lower concentrations of its two main active ingredients, mitragynine and 7-hydroxymitragynine, than some refined products that have recently become available. Think coffee beans versus processed caffeine, or cannabis flower versus distilled THC.</p>
<p>For some people, discontinuing regular kratom use may result in relatively mild <a href="/quitting-kratom-addiction/">withdrawal symptoms</a>. Certain studies, some of which Haddow would dispute, have additionally associated kratom with side effects such as agitation, cardiac problems, hallucinations, weight loss, insomnia and seizures—yet even those found that such harms most frequently occur at high doses or when used alongside other drugs.</p>
<blockquote><p>The model legislation backed by the American Kratom Association is called the Kratom Consumer Protection Act.</p></blockquote>
<p>The American Kratom Association is hoping to get ahead of the controversy as public awareness of kratom grows and lawmakers feel pressure to act. In addition to trying to combat what it sees as misinformation, the organization has spent the past few years working to pass state-level legislation that would set basic guardrails around kratom while ensuring it remains available to adult consumers.</p>
<p>The model legislation backed by the group is called the Kratom Consumer Protection Act (KCPA). Broadly speaking, it sets a minimum age of 18 to buy kratom products (though some states have made it 21), prohibits the addition of adulterants or “any synthetic or artificially elevated alkaloid content,” requires that manufacturers register with the proper regulatory authority, and creates standards around packaging and labeling.</p>
<p>“Labeling is critically important,” Haddow said. That means not only what’s in the product but also who processed and packaged it.</p>
<p>“One of the most important things on the label is who manufactured it and what their address is, because too many kratom products today have no identifiers,” he explained. “If you have an adverse event, you don’t know who to report it to—or report on—because there’s no information that’s available.”</p>
<p>So far, seven states have already enacted some form of KCPA: Arizona, Colorado, Georgia, Nevada, Oklahoma, Oregon and Utah. Lawmakers in Virginia and West Virginia, meanwhile, just passed their own versions of KCPA bills earlier this year. Similar legislation is also making its way through the Texas legislature.</p>
<p>In Missouri, a bill to regulate kratom passed the legislature last year but was vetoed by Gov. Mike Parson (R). Haddow said he has a meeting scheduled with the governor and his staff, “and we’re going to work through whatever their objections were.”</p>
<p>“We’ve been able to answer most of that,” he continued, “and we’re going to clarify that they’re going to sign the bill that passed last time, so that’ll be run again.”</p>
<p>Georgia already has a form of KCPA in place, but lawmakers introduced a ban this session. Haddow and the American Kratom Association pushed back, and the bill has since been amended. Haddow hopes the final version might even strengthen the KCPA.</p>
<p>Haddow said his group is also on the cusp of helping overturn a kratom ban on the books in Vermont. “We petitioned the state of Vermont, the Department of Health, and they approved our petition to reform the drug rule in Vermont on March 1,” he said. The state must next go through rulemaking, although officials are holding off until the end of the session to see whether lawmakers pass a regulation bill that‘s pending in the legislature.</p>
<p>Similar efforts are underway in Wisconsin, Rhode Island and Arkansas. In Indiana, lawmakers are currently considering legislation to repeal a ban and pass a version of the KCPA.</p>
<p>Like other drug policy reform advocates, Haddow has his complaints about stubborn, evidence-blind law enforcement associations and reactive politicians, quick to attack what they don’t understand.</p>
<p>When it comes to Alabama? “That’s just a tough state,” he said. “The district attorneys association was responsible for getting kratom banned in the first place, and they’re just locked and loaded against kratom. They don’t care about facts. They don’t care about any data. I think if the Savior Himself came down and said, ‘Kratom is good,’ they wouldn’t care.”</p>
<blockquote><p>“I tell my wife it’s because I’m a great lobbyist, but the truth is, it’s because kratom’s less well known.”</p></blockquote>
<p>Despite the holdouts, the American Kratom Association and other advocates have had some remarkable successes in winning over politicians. Reform efforts around more mainstream drugs, such as cannabis or psychedelics, have in some cases spent decades struggling to overcome entrenched stigma and stereotypes.</p>
<p>“I tell my wife it’s because I’m a great lobbyist, but the truth is, it’s because [kratom]’s less well known,” Haddow said. “The only thing I have to fight, and the AKA advocates have to fight, is googling kratom. State lawmakers don’t know what it is, and so they google it.”</p>
<p>Haddow noted that kratom only entered the US in significant amounts in the 1970s, after soldiers encountered the plant during the Vietnam War. Compared with many other drugs, there has been far less time for stigma against kratom to embed itself in US culture and politics.</p>
<p>And unlike other drugs, despite that 2016 DEA effort, kratom still isn’t covered under the federal Controlled Substances Act. Haddow wants it to stay that way. While kratom should be regulated for safety and quality and kept out of the hands of children, he said, adults should be trusted to make the decision to use it.</p>
<p>“I spoke with an FDA official today, and he was telling me that one of the biggest concerns the FDA has about kratom is that people are sitting at home and self-medicating with it, and they’re trying to get off opioids,” he said from Vienna. “I think that strips people not only of their freedom but of their dignity.”</p>
<p>If people are self-medicating at home for this purpose, he continued, with a substance that has a low risk profile, “I want people to have access to that.”</p>
<p>&nbsp;</p>
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<p><em>Photograph by drogen.bz via <a href="https://commons.wikimedia.org/wiki/File:Kratom_%28Mitragyna_speciosa%29_Sumatra_White_Vein_20g.jpg">Wikimedia Commons</a>/<a href="https://creativecommons.org/licenses/by/3.0/deed.en">Creative Commons 3.0</a></em></p>
<p><a class="a2a_button_facebook" href="https://www.addtoany.com/add_to/facebook?linkurl=%2Fkratom-legal-bans%2F&linkname=%E2%80%9CLawmakers%20Have%20to%20Google%20It%E2%80%9D%3A%20Inside%20the%20Struggle%20to%20Regulate%20Kratom" title="Facebook" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_twitter" href="https://www.addtoany.com/add_to/twitter?linkurl=%2Fkratom-legal-bans%2F&linkname=%E2%80%9CLawmakers%20Have%20to%20Google%20It%E2%80%9D%3A%20Inside%20the%20Struggle%20to%20Regulate%20Kratom" title="Twitter" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_email" href="https://www.addtoany.com/add_to/email?linkurl=%2Fkratom-legal-bans%2F&linkname=%E2%80%9CLawmakers%20Have%20to%20Google%20It%E2%80%9D%3A%20Inside%20the%20Struggle%20to%20Regulate%20Kratom" title="Email" rel="nofollow noopener" target="_blank"></a></p><p>The post <a href="/kratom-legal-bans/">“Lawmakers Have to Google It”: Inside the Struggle to Regulate Kratom</a> appeared first on <a href="/">Filter</a>.</p>
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		<title>People&#8217;s Reasons for Using Kratom Are Rapidly Diversifying</title>
		<link>/kratom-use-diversifying/</link>
		
		<dc:creator><![CDATA[Doug Johnson]]></dc:creator>
		<pubDate>Mon, 11 Jul 2022 13:47:12 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Use + Harm Reduction]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[opioids]]></category>
		<category><![CDATA[science]]></category>
		<guid isPermaLink="false">/?p=14663</guid>

					<description><![CDATA[<p>Since kratom began growing in popularity in North America, researchers have tried to understand how and why people are using ...</p>
<p>The post <a href="/kratom-use-diversifying/">People&#8217;s Reasons for Using Kratom Are Rapidly Diversifying</a> appeared first on <a href="/">Filter</a>.</p>
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										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">S</span>ince kratom began growing in popularity in North America, researchers have tried to understand how and why people are using it. Much research focuses on people using the plant to ease the symptoms of opioid withdrawal, since the Southeast Asian plant works on similar neurotransmitter receptors to opioids. <span style="font-weight: 400;">One </span><a href="https://www.jwatch.org/na50943/2020/02/24/why-people-use-kratom-results-online-survey"><span style="font-weight: 400;">2020 study</span></a><span style="font-weight: 400;">, for instance, found that 41 percent of nearly 3,000 respondents used kratom for this purpose.</span></p>
<p><span style="font-weight: 400;">The National Institute on Drug Abuse (NIDA), which funds something like 80 percent of the world’s drug research, has sometimes been </span><a href="/drug-research-ignores-pleasure/"><span style="font-weight: 400;">criticized</span></a><span style="font-weight: 400;"> for its overwhelming focus on “drug abuse and addiction” at the expense of pleasure and benefits. However, <a href="https://www.tandfonline.com/eprint/BWUQUPBFTI2DKR2MKNDC/full?target=10.1080/00952990.2022.2083967">new research</a> out of the US federal institute suggests that people&#8217;s reasons for using kratom have changed and expanded.</span></p>
<p><span style="font-weight: 400;">To look into this, the research team re-contacted respondents from a previous study (which ran between September 2020 and March 2021 and surveyed people who used alcohol, opioids, or stimulants in the prior six months) who had reported past kratom use. The respondents in the past study had been recruited using Amazon Mechanical Turk, an online crowdsourcing platform.</span></p>
<p><span style="font-weight: 400;">The kratom research team reached out to 289 people, of whom 129 took the survey about their kratom use. All were located in the United States, and aged 18 or over. </span><span style="font-weight: 400;">It was “essentially a convenience sample, but it had greater diversity in terms of use experiences compared to a lot of the other online kratom surveys,” Dr. Kirsten Smith, a NIDA researcher and one of the paper’s authors, told </span><i><span style="font-weight: 400;">Filter.</span></i></p>
<blockquote><p><span style="font-weight: 400;">Interestingly, the mean age at which respondents first tried kratom was 29.9—older than is the case for most other drugs.</span></p></blockquote>
<p><span style="font-weight: 400;">Of the respondents, 48.5 percent ranked kratom as a “preferred substance.” </span><span style="font-weight: 400;">And while </span><span style="font-weight: 400;">previous NIDA</span><a href="https://nida.nih.gov/publications/research-reports/substance-use-in-women/sex-gender-differences-in-substance-use"><span style="font-weight: 400;"> research</span></a><span style="font-weight: 400;"> points to men using illicit drugs at higher rates than women, a slight majority of the kratom sample were women. The sample was mostly white, which speaks to the need for more targeted research into other demographics.</span></p>
<p><span style="font-weight: 400;">The paper notes that in the US, kratom use increased from around 2007, but remained rare until 2015. Many of the respondents reported trying kratom for the first time after 2015. And interestingly, the mean age at which respondents first tried kratom was 29.9—older than is the case for most other drugs studied (buprenorphine, a drug prescribed for opioid use disorder, is one exception).</span></p>
<p><span style="font-weight: 400;">Smith said that this warrants more research. However, she believes that as kratom grows in popularity, the age at which people try it for the first time may decrease. “People who are younger will now know about it,” she said.</span></p>
<p><span style="font-weight: 400;">While some believe kratom could act as a “gateway drug” to opioids, Smith said that this seems unlikely based on what she’s heard anecdotally and the fact that kratom, in the US, is relatively new. </span></p>
<p><span style="font-weight: 400;">On the other hand, there are</span><a href="https://www.healio.com/news/primary-care/20210423/most-people-use-kratom-to-selfmanage-opioid-addiction"> <span style="font-weight: 400;">many reported cases</span></a><span style="font-weight: 400;"> of people using kratom to wean themselves off opioid use, to </span><a href="/kratom-mental-health-opioids/"><span style="font-weight: 400;">replace opioids</span></a><span style="font-weight: 400;">, or to stave off opioid withdrawal symptoms while opioids are unavailable to them, as Smith acknowledged. Many of the study respondents reported using kratom as an opioid substitute, but also as a substitute for alcohol or stimulants.</span></p>
<p><span style="font-weight: 400;">Fascinatingly, in this context, the study found that the other drug with the “strongest association with past-year kratom use” was vaped nicotine, which is typically used as a harm reduction substitute for tobacco. Past-month kratom use, meanwhile, was most strongly associated with past-month use of cannabis, which is itself sometimes described as an “</span><a href="https://sponsored.bostonglobe.com/weedmaps/cannabis-the-exit-drug/"><span style="font-weight: 400;">exit drug</span></a><span style="font-weight: 400;">” for opioids.</span></p>
<blockquote><p><span style="font-weight: 400;">In the research, 48.1 percent of respondents said kratom boosts energy. And some people take it before</span> <span style="font-weight: 400;">working out</span><span style="font-weight: 400;">, Smith said.</span></p></blockquote>
<p><span style="font-weight: 400;">However, people also use kratom for various completely different reasons—and the number of reasons for kratom use appears to be growing. “The motivations are so important to understand the kratom story,” Smith said.</span></p>
<p><span style="font-weight: 400;">In the research, 48.1 percent of respondents said kratom boosts energy. And some people take it before</span><a href="https://grhkratom.com/using-kratom-as-a-pre-workout-kratom-before-working-out/"> <span style="font-weight: 400;">working out</span></a><span style="font-weight: 400;">, Smith said. Others may look at it as a</span><a href="https://www.hopkinsmedicine.org/news/newsroom/news-releases/natural-herb-kratom-may-have-therapeutic-effects-and-relatively-low-potential-for-abuse-or-harm-according-to-a-user-survey"> <span style="font-weight: 400;">herbal supplement</span></a><span style="font-weight: 400;">, considering 29.5 percent of respondents reported purchasing kratom at herbal/vitamin stores. People also simply use kratom to relax enjoyably, vaguely similar to how people might drink wine after work—48.8 percent of respondents said they used it this way. Other people might want to use kratom to address pain, or to take it before work just to feel a little better.</span></p>
<p><span style="font-weight: 400;">Others still may use it to self-treat things like ADD, anxiety symptoms or chronic fatigue—as such, some people are using it to address gaps in health care, Smith said. She doesn’t believe that these groups represent the majority of kratom users at the moment, but the nature of how most people use the drug may change going forward.</span></p>
<p><span style="font-weight: 400;">“You have people who are the early adopters getting it online … The first cohort of users in the United States were very much in that self-treatment kind of group,” Smith said. “And then you start to see a shift as products become commercially available in all these different forms, and marketed in different ways.”</span></p>
<p><span style="font-weight: 400;">Kratom grows in various Southeast Asian countries like Indonesia and Thailand. It is regularly sold as a powder made from leaves of the plant, as capsules filled with the powder, or as tinctures, among other formulations.</span></p>
<blockquote><p><span style="font-weight: 400;">If the motivations Smith emphasized are to be fully understood, a lot more research will be needed.</span></p></blockquote>
<p><span style="font-weight: 400;">The most abundant chemical in kratom is mitragynine, which is largely considered the compound that produces the relatively mild high. However,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053747/#:~:text=Kratom%20contains%20over%20forty%20alkaloids,the%20remaining%20alkaloids%20are%20limited."> <span style="font-weight: 400;">one study</span></a><span style="font-weight: 400;"> suggests that there are around 40 different alkaloids present in kratom leaves, and they can vary wildly from strain to strain—or even plant to plant, depending on numerous factors like where the plant is grown, when it is harvested, etc. This makes gauging the subjective and chemical effects of kratom difficult.</span></p>
<p><span style="font-weight: 400;">Kratom exists in a kind of legal gray zone in the United States, as it has not been approved for consumption by humans by the FDA, but is not federally illegal to sell. However, some states, such as</span><a href="https://www.therecoveryvillage.com/kratom-addiction/is-kratom-legal-in-my-state/"> <span style="font-weight: 400;">Alabama</span></a><span style="font-weight: 400;">, have made it illegal. There are myriad websites that sell kratom online, but in some parts of the US, it can also be purchased in brick-and-mortar shops.</span></p>
<p><span style="font-weight: 400;">The NIDA paper provides a glimpse into people’s rapidly diversifying reasons for kratom use, but if the motivations Smith emphasized are to be fully understood, a lot more research will be needed. Further, considering the sheer breadth of potentially psychoactive compounds in the plant, the dearth of research on withdrawal and other knowledge gaps, there’s a great deal more to learn.</span></p>
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<p><em>Photograph by Morgan Godvin</em></p>
<p><a class="a2a_button_facebook" href="https://www.addtoany.com/add_to/facebook?linkurl=%2Fkratom-use-diversifying%2F&linkname=People%E2%80%99s%20Reasons%20for%20Using%20Kratom%20Are%20Rapidly%20Diversifying" title="Facebook" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_twitter" href="https://www.addtoany.com/add_to/twitter?linkurl=%2Fkratom-use-diversifying%2F&linkname=People%E2%80%99s%20Reasons%20for%20Using%20Kratom%20Are%20Rapidly%20Diversifying" title="Twitter" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_email" href="https://www.addtoany.com/add_to/email?linkurl=%2Fkratom-use-diversifying%2F&linkname=People%E2%80%99s%20Reasons%20for%20Using%20Kratom%20Are%20Rapidly%20Diversifying" title="Email" rel="nofollow noopener" target="_blank"></a></p><p>The post <a href="/kratom-use-diversifying/">People&#8217;s Reasons for Using Kratom Are Rapidly Diversifying</a> appeared first on <a href="/">Filter</a>.</p>
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		<title>Quitting Kratom Reminded Me How Little Drugs Have to Do With Addiction</title>
		<link>/quitting-kratom-addiction/</link>
		
		<dc:creator><![CDATA[Morgan Godvin]]></dc:creator>
		<pubDate>Thu, 23 Jun 2022 13:00:10 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Use + Harm Reduction]]></category>
		<category><![CDATA[addiction]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[treatment]]></category>
		<guid isPermaLink="false">/?p=14578</guid>

					<description><![CDATA[<p>“I admitted I was powerless over my addiction” is a phrase I only uttered under extreme duress, monitored by a ...</p>
<p>The post <a href="/quitting-kratom-addiction/">Quitting Kratom Reminded Me How Little Drugs Have to Do With Addiction</a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">“</span>I admitted I was powerless over my addiction” is a phrase I only uttered under extreme duress, monitored by a rehab counselor who controlled my fate. It never rang true for me, despite the heroin addiction. Seeing as how I couldn’t get past Step One, I could never glean any benefit from 12-step. Being forced to return to something that did not work for me soured me to the thought of treatment itself, until I resigned myself to a life and death in addiction.</p>
<p>I didn’t need the Steps to quit heroin. And my recent experience of quitting kratom after nine months of daily use has only cemented my suspicion: We are <em>not</em> powerless over the drugs we use.</p>
<p>Type “kratom withdrawal” into Google and you will see a series of addiction treatment centers and SAMHSA warnings. Where there is money to be made, there is pristine search engine optimization. <i>Surprise</i>, you can go to an expensive inpatient detox and rehab for this plant.</p>
<p>Spend any time on the r/quittingkratom subreddit, and you’ll be left with an even more dire impression of the drug. People lament the green sludge that has robbed them of their lives, turned them into recluses only focused on their next dose, driven them into poverty, all the while beleaguered by withdrawals comparable to heroin.</p>
<p>When I made the conscious decision to take kratom daily, deciding that the benefits outweighed the cost, I knew the day would come that I would need to taper off of it entirely. Thanks to my raging PTSD from being<a href="https://www.themarshallproject.org/2020/09/03/i-thought-jail-would-help-me-get-clean-i-was-dead-wrong"> force-detoxed</a> into withdrawal at the county jail, I always held a healthy skepticism of any substance that required daily dosing. For this reason, and the fact that there is scant research about long-term or heavy kratom use, I always kept my dose low. When tolerance left it creeping upward, I would dramatically reduce for a week to “reset.” But I never completely stopped.</p>
<p>Thanks, once again, to criminal-justice system traumas, however, I’m now massively wary of breaking laws. I regret that that sentence could be read by some as a justification of punitive policies; it should not be. Nonetheless, it’s true for me. So when my best friend suggested that we visit the UK this summer, I knew what it meant. Kratom is a banned substance there. I would have to taper all the way off.</p>
<p>Because of my felonies, I had to apply for a tourist visa even though most Americans don’t need one. While I waited, I read up what the tapering journey would be like. It filled me with fear. Dozens of people reported horrific opioid-like withdrawals, mental cravings and an inability to cease using. People described 100 gram per day habits—meaning you’d consume an entire kilo in a 10-day span. (That’s still only $200 a month—an expense, certainly, but I feel like the “kratom impoverished me” complaint should be taken in the context of the overpriced, adulterated illicit opioids that some of us kratom users were previously paying for.) It all felt unbelievable to me, as I’d hovered between 4 and 12 grams a day and preferred the low end of that range.</p>
<blockquote><p>Such absolutist portrayals on both ends of the spectrum frustrate me.</p></blockquote>
<p>I became increasingly trepidatious about the task. In r/quittingkratom, most people go cold turkey, or “CT” in the lingo. Despite the fact that slow tapers, in my experience, almost entirely mitigate withdrawal symptoms, the people in the subreddit described finding it too challenging to resist temptation and stick to a taper schedule. Others said they found dose-reduction withdrawals to be so similar to CT that it didn’t matter.</p>
<p>In r/kratom, on the other hand, it’s almost entirely rainbows and sunshine. <i>Miracle drug</i>! <i>Lifesaving</i>! Despite the benefits I found in kratom, such absolutist portrayals on both ends of the spectrum frustrate me—which is why I made sure to acknowledge my physical dependency when I <a href="/kratom-mental-health-opioids/">outed myself</a> as a kratom user some months ago.</p>
<p>I ended up buying the supplements random strangers on the internet recommended, some of which have an evidence base and some of which don’t. I liked the black seed oil, which I’d previously used to potentiate my dose. I megadosed vitamin C, and took more things that I won’t go into because of the haywire nature of the <a href="https://www.theatlantic.com/health/archive/2021/11/dietary-supplements-mutlivitamins/620776/">unregulated US supplement market</a>. I threw everything at the wall to see what stuck. (Something was working, because I would feel worse when I forget to take my meal-sized handful of “supplements.”)</p>
<p>I was enthralled by all the r/quittingkratom accounts of true addiction, in which people’s desire to live their life, have sex, have fun or do anything else was completely supplanted by their kratom use. Were we using the same substance?</p>
<p>I started by cutting out my occasional midday doses, then began lowering my morning and evening doses. I got down to 2 grams per day within a couple of weeks. I had little trace of opioid withdrawal, with which I am intimately familiar. Sleep became more challenging, and the mental health symptoms that made me take kratom in the first place felt more intense, but quickly everything regulated. (Not that my baseline is all that great.)</p>
<p>But I did have an unexpected symptom: <a href="https://www.medicalnewstoday.com/articles/brain-zaps">brain zaps</a>, which sometimes radiated throughout my body, resulting in panicked consultations with friends of mine who “get it”—read: a medical student and a generous psychiatry resident. I had felt “shocks” once before, after tapering off of prescription Xanax more quickly than my psychiatrist advised. (My need to prove I have power over drugs seems ingrained.) Concerned that it was GABA withdrawal like from the benzos, which does pose a seizure risk, I took a low dose of a leftover prescription benzodiazepine. It didn’t abate the shocks; this was my very <i>ad ho</i>c diagnostic tool to confirm that the shocks were instead related to the neurotransmitter serotonin. A flurry of Reddit searches confirmed it&#8217;s a semi-common symptom. I wish there were more peer-reviewed literature; I researched heroin exhaustively back in the days of Bluelight, but find kratom to be mostly a black hole.</p>
<p>To my best guess, kratom functions as an SSRI. This is suggested by <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309668/">research</a> on its hypothetical mechanism of action. My taper was slow enough to avoid opioid-like withdrawal symptoms but too fast to avoid SSRI-style withdrawal. I sat at 2 grams daily for two more weeks, but struggled to get below that amount. Less than that felt exactly the same as none at all. It was time to jump off.</p>
<blockquote><p>Drugs are not good or bad. It is our <em>relationships</em> to them, influenced by many outside variables, that form the crux of our subjective experiences.</p></blockquote>
<p>I took my last dose Saturday morning. I didn’t experience so much as any discomfort. On Sunday, I went hiking. On Monday, I went to a Pride Gay Skate event at the roller rink. And it struck me anew how little drug addiction has to do with the drug itself.</p>
<p>There are some important caveats to my personal experience. I may be formerly incarcerated with mental health challenges, but I am not subjected to extreme poverty, racism or any number of other stressors that heavily impact people’s management of their relationships with drugs. Yet none of these very real societal factors are <i>inherent</i> to any drug—and that’s the point.</p>
<p>Drugs are inanimate substances. They are not good or bad. It is our <em>relationships</em> to them, influenced by many outside variables, that form the crux of our subjective experiences. Human beings are so desperate to externalize our internal emotions, to find something else to obsess over beyond our existential dread. I realized this once, fresh out of inpatient treatment, pulled over on the side of the road with the Domino’s Pizza sign alit on top of my car midway through my shift, gasping for air as I descended into a panic attack.</p>
<p><i>It’s because I need heroin, </i>I told myself. <i>That’s not true but it will become a self-fulfilling prophecy if you believe it, </i>some wiser part of myself responded. We want a way to make the incomprehensible digestible. Identifying an external, concrete source of our troubles—rather than the complex interplay of psychological and societal circumstances—is relatively reassuring.</p>
<p><i>This anxiety is because I need heroin</i>. Believe in your inherent need, and you have a clear remedy. And heroin <i>will</i> help, at least initially. But if instead you tell yourself a different story—like, this is anxiety that reflects aspects of my life, but experience tells me it will subside—that might become true, too. There’s a venerable <a href="https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1360-0443.91.12s1.7.x">study</a>, led by William R. Miller, co-creator of motivational interviewing, that reflects these ideas. For people with alcohol addiction, it found, two factors were “optimally predictive of resumed drinking.” Those were: “lack of coping skills and belief in the disease model of alcoholism.”</p>
<p>It is never really about the drug. The vast majority of people who try any drug never become addicted, contrary to popular lore. It’s about the relationship, and as with other relationships, we sometimes adopt toxic dynamics.</p>
<p>I do not doubt that people struggling with kratom addiction are, in fact, struggling. To those who went to inpatient only to resume addictive use, my heart goes out to you. I know that pain. But I also know that <a href="/behavioral-addictions/">addictive relationships with non-drug behaviors</a> can be just as painful. And I know that kratom is a relatively mild substance that can be successfully tapered with few ill effects—<i>if </i>other variables allow it.</p>
<p>Funnily enough, the UK ended up denying my visa. But I wanted to prove to myself that I could endure the withdrawals, taper and quit anyway. And I did.</p>
<blockquote><p>Telling people they’re powerless over a drug carries the severe risk of making them believe it.</p></blockquote>
<p>Though I’d rather not test it, I do believe that my life is purposeful enough today that even taking heroin wouldn’t lure me back into compulsive, uncontrolled use. My relationship to that substance has changed because my relationship to myself has changed.</p>
<p>Most critically, my social context has changed. I am not, as I once was, an impoverished adolescent with no hope for my future, living an unequivocally miserable life. While I still struggle with suicidal ideation, unlike before I went to prison, it no longer feels like the most rational choice. (Its profound irrationality bothers me most, in fact.) After military benefits supported me through a bachelor’s degree, I have found work that supports me financially and that I find meaningful.</p>
<p>Many people do not share these privileges, and the unequal toll of addiction damningly reflects the injustices of our society. At the same time, knowing what addiction is <i>not</i> can be empowering to anyone. It isn’t the drug. And telling people they’re powerless over a drug carries the severe risk of making them believe it.</p>
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<p><em>Photograph by Morgan Godvin</em></p>
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		<title>Kratom Helps Me Cope With Life, So What’s the Problem? </title>
		<link>/kratom-mental-health-opioids/</link>
		
		<dc:creator><![CDATA[Morgan Godvin]]></dc:creator>
		<pubDate>Thu, 10 Mar 2022 18:24:55 +0000</pubDate>
				<category><![CDATA[FilterMag]]></category>
		<category><![CDATA[Use + Harm Reduction]]></category>
		<category><![CDATA[benzodiazepines]]></category>
		<category><![CDATA[kratom]]></category>
		<category><![CDATA[mental health]]></category>
		<category><![CDATA[opioids]]></category>
		<category><![CDATA[recovery]]></category>
		<guid isPermaLink="false">/?p=14025</guid>

					<description><![CDATA[<p>A kilo is surprisingly heavy, I thought as I dropped the package onto my mattress with a thud. I never ...</p>
<p>The post <a href="/kratom-mental-health-opioids/">Kratom Helps Me Cope With Life, So What’s the Problem? </a> appeared first on <a href="/">Filter</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="wpsdc-drop-cap">A</span><i><span style="font-weight: 400;"> kilo is surprisingly heavy, </span></i><span style="font-weight: 400;">I thought as I dropped the package onto my mattress with a thud. I never thought I would return to the life of digital scales and weighing grams, but here I am. Except it’s not illegal drugs (this time), it’s kratom.</span></p>
<p><span style="font-weight: 400;">A cousin of the coffee plant, kratom is a tree native to Southeast Asia. Its leaves are shredded into a bitter green powder and sold across the world. I order mine online, avoiding the low-grade product sold at gas stations and headshops.</span></p>
<p><span style="font-weight: 400;">Over the six months since I began using kratom, I haven’t been mentioning my use to many people, and certainly not in addiction-recovery circles. Decades of drug-war rhetoric baked irrational fears into the American psyche. If the drug isn’t alcohol or caffeine, it is insidious. Except anyone who has taken kratom realizes how bogus this is.</span></p>
<blockquote><p><span style="font-weight: 400;">Kratom makes my days livable, manageable.</span></p></blockquote>
<p><span style="font-weight: 400;">I take the herbal supplement two or three times daily, which ends up costing me about $1 per day.</span> <span style="font-weight: 400;">It would be cheaper (and faster-acting) if I only used the powdered form, which I sometimes do by making a sealed “taco” of Japanese potato starch disks called oblate papers. With a preference for speed and convenience, I usually take pre-filled capsules.</span></p>
<p><span style="font-weight: 400;">Its effects are mild, don’t impair me in any way, and have a natural ceiling—a consequence of kratom having both agonist and antagonist opioid-like properties. When I found a dose that worked for me, I stayed there, raising only incrementally to combat inevitable tolerance before going on “tolerance breaks.” Kratom makes my days livable, manageable.</span></p>
<p><span style="font-weight: 400;">The herb is not on our banned drugs list more by chance—including its former obscurity in the United States—than design. But there are </span><a href="/ohio-plans-to-ban-kratom-and-the-dea-may-be-close-behind/"><span style="font-weight: 400;">periodic threats</span></a><span style="font-weight: 400;"> to this status. When there </span><a href="/fda-international-kratom-ban/"><span style="font-weight: 400;">was talk</span></a><span style="font-weight: 400;"> of an international ban, which </span><a href="/who-kratom-ban/"><span style="font-weight: 400;">for now has not materialized</span></a><span style="font-weight: 400;">, I felt the vice grip of the drug war once again.</span></p>
<p><span style="font-weight: 400;">I was addicted to heroin for years and, as a direct result, was in prison for years after that. Then came the random urinalyses and the perpetual fear. Once, the day after a doctor’s visit where my physician told me to drink more water because my blood pressure was low, my urinalysis sample came up “dilute” at the federal probation office, a punishable offense. I had long since quit opioids, but trace amounts of THC (whether from CBD or unwittingly consuming even the residue of edibles) could have sent me back to prison. I avoided all supplements, however natural, for fear of contamination.</span></p>
<p><span style="font-weight: 400;">My mental health suffered. If suicidality is a scale, I never get below a four out of 10. Some days are worse than others, with shocking amounts of my mental energy consumed by batting back thoughts of suicide. On the outside, this can look like laziness or paralysis. But merely existing in that moment, without taking a gun to my head,</span> <span style="font-weight: 400;">is the best I can do. The pandemic first triggered my jail-learned fear of infectious disease, thanks to being confined in overcrowded spaces with lice and tuberculosis for four years. Later, the pandemic restrictions caused another trigger for my PTSD as I felt trapped and confined.</span></p>
<p><span style="font-weight: 400;">The solution? Xanax. I was mostly living abroad during that time, where Big Pharma panic never took hold because opioid prescribing never took off. A psychiatrist prescribed me Xanax and encouraged me to try SSRIs, which I wouldn’t do (I have since softened). I had once binged benzos and feared that if I took one pill, I would end up with a needle in my arm the next day. But it didn’t happen. I used the medication when I needed it, never escalated my dose or frequency, and tapered off easily once my panic subsided. I learned then that addiction is not a fixed mental state, but rather a consequence of circumstance.</span></p>
<blockquote><p><span style="font-weight: 400;">Back in the United States, my distant addiction history disqualified me for prescription benzodiazepines.</span></p></blockquote>
<p><span style="font-weight: 400;">Back in the United States, my distant addiction history disqualified me for prescription benzodiazepines, despite my having used them without problems for an entire year. Left without pharmaceutical support, I began looking into alternatives for my anxiety, depression and chronic suicidal ideation.</span></p>
<p><span style="font-weight: 400;">Mostly, I fantasized about doing heroin. Being appointed to the Measure 110 Oversight and Accountability Council to oversee </span><a href="/drug-decriminalization-oregon/"><span style="font-weight: 400;">Oregon’s drug decriminalization</span></a><span style="font-weight: 400;"> has been one of the most challenging experiences of my professional career. However rewarding it may be, we find ourselves</span> <span style="font-weight: 400;">under constant, public pressure. I had never gotten so close to returning to heroin.</span></p>
<p><span style="font-weight: 400;">That’s when I found kratom. I’m a researcher, so naturally, I researched it exhaustively. Various subreddits provided ample material. With a sample size of thousands upon thousands of posts, I could glean clear patterns.</span></p>
<p><span style="font-weight: 400;">People use kratom for opioid replacement theory, opioid withdrawal management, chronic pain, anxiety, depression and other mental health woes. Others use it as a pre-workout supplement, for mild euphoria, or to make shift work more bearable. (Traditionally, it was used by Southeast Asian laborers working long hours in the sun.)</span></p>
<p><span style="font-weight: 400;">Few of these thousands of accounts of benefits are reflected in academic research. With few exceptions, kratom studies are retrospective, which introduces inherent negative bias. No one walks into the emergency department to tell you that kratom cut their pain in half; people walk in because something negative has occurred.</span></p>
<p><span style="font-weight: 400;">Of the few documented cases of kratom-involved death, virtually all had other substances present. It does not cause respiratory depression, unlike opioids. As </span><a href="/fentanyl-buprenorphine-microdosing/"><span style="font-weight: 400;">buprenorphine induction</span></a><span style="font-weight: 400;"> for people using fentanyl becomes increasingly difficult, could kratom be used as withdrawal relief? I think so, but without legal standing I cannot do a randomized control trial and have it be ethical. It’s a catch-22.</span></p>
<p><span style="font-weight: 400;">Kratom does cause physical dependency, and that can be downplayed by its advocates. It has effects on the kappa opioid receptors, among other mechanisms. It has both mildly sedating and stimulant effects, a unique mix for a molecule. Now, when I go more than 14 hours without kratom, I have mild temperature dysregulation. I feel hot or cold, sweat. Anyone who has experienced opioid withdrawal is familiar with this symptom.</span></p>
<p><span style="font-weight: 400;">But critically, it stops there. My nose might run, my eyes water, but I feel fine. I’ll have trouble falling asleep, the most annoying symptom. But the very mild withdrawals can be averted by even rapid tapers, which I sometimes do for my tolerance breaks. When I stopped taking Xanax, I wrote out a schedule and stuck to it, and the same can be done with kratom.</span></p>
<p><span style="font-weight: 400;">Upon stopping, I do feel depressed and suicidal. But is that from withdrawal, or simply a return to baseline?</span> <span style="font-weight: 400;">Kratom is not a magic bullet. I still struggle with mental health most days. But at least I have something reliable to lean on that is unlikely to harm me.</span></p>
<blockquote><p><span style="font-weight: 400;">For me, as for many others, kratom is the epitome of harm reduction when used as a replacement for far riskier alternatives.</span></p></blockquote>
<p><span style="font-weight: 400;">Problems might arise only when use is stopped suddenly, as often happens with unregulated drugs whose supply is unreliable. There have certainly been issues with the kratom supply chain. Like all things billed “supplements” in the United States, it has almost no government regulations. It has been found adulterated with everything from bacteria to actual drugs. (I highly recommend Amanda Mull’s feature</span><a href="https://www.theatlantic.com/health/archive/2021/11/dietary-supplements-mutlivitamins/620776/"> <span style="font-weight: 400;">Everything is a Multivitamin</span></a><span style="font-weight: 400;"> about the deregulated chaos of the industry.)</span></p>
<p><span style="font-weight: 400;">These incidents have been used in calls to ban the substance but they’re evidence that more consumer protections are needed, not prohibitions. Kratom regulation bills, to enhance such protections, have passed in several states, </span><a href="https://oregoncapitalchronicle.com/briefs/legislature-moves-towards-approval-of-a-bill-that-would-regulate-kratom/"><span style="font-weight: 400;">Oregon</span></a><span style="font-weight: 400;"> included.</span></p>
<p><span style="font-weight: 400;">If kratom were banned tomorrow, or the supply failed completely, I would probably end up </span><a href="/blues-west-coast-drugs/"><span style="font-weight: 400;">on Blues</span></a><span style="font-weight: 400;">. Without something, however mild, to tickle my opioid receptors, I am a hulking mass of raw nerves, existential dread and anxiety. For me, as for many others, kratom is the epitome of harm reduction when used as a replacement for far riskier alternatives.</span></p>
<p><span style="font-weight: 400;">Why are a few non-prescribed drugs legal, and the rest banned? A mix of chance, racism, oppression and evidence-averse legislators. And yet for six months, I hesitated to share publicly that I use the substance. It doesn’t cause me intoxication and it helps, rather than hinders, me in getting through daily life. But in most recovery circles, it jeopardizes my status as a person in long-term recovery. It can also jeopardize my access to high-quality healthcare, as providers are wont to blame any symptom on this herb they do not understand.</span> <span style="font-weight: 400;">The internalized shame and stigma persist.</span></p>
<p><span style="font-weight: 400;">The days of demonizing drugs can and must be over. Kratom provides myriad benefits to people who use it, and could have substantial applications in addiction medicine and chronic pain treatment. But no form of drug use is cause for shame. I refuse to hide in the shadows any longer.</span><span style="font-weight: 400;"> </span></p>
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<p><em>Photograph by <a href="http://www.drogen.bz/">drogen.bz</a> via <a href="https://commons.wikimedia.org/wiki/File:Kratom_(Mitragyna_speciosa)_Sumatra_White_Vein_20g.jpg">Wikimedia Commons</a>/<a href="https://creativecommons.org/licenses/by/3.0/deed.en">Creative Commons 3.0</a></em></p>
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